Stem Cells for Cerebral Palsy (CP): Extensive analysis from various research organizations over the last decade has led to the termination that stem cell transplantation is the most hopeful treatment modality not only to enhance the condition and stop secondary complications but further to reverse the neurological damage.
Furthermore, stem cells regulate the immune system’s response against the nerve cells and release growth factors that promote cell growth, differentiation, and stimulation of the brain’s own stem cells to promote up the recovery process.
How Stem Cell Therapy Works
There are various types of stem cell technologies that are being used to treat Cerebral Palsy patients and have proved an encouraging potential for clinical purposes. Mesenchymal Stem Cells (MSCs) are one of the fabulous studied types of stem cells to treat Cerebral Palsy patients. The mechanisms of Mesenchymal Stem Cell transplantation are:
(1) Reducing the in ammatory replication and evading secondary brain lesion;
(2) Adapting into neurons, astrocyte, microglia, and oligodendrocyte, that help to repair myelin sheath, developing axon regeneration, and increasing frequency of nerve impulses;
(3) performing the cytokines and growth factors, such as nerve growth factor (NGF),glial-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), neurotrophin 4/5 (NT 4/5) which promote brain neuroprotection,
(4) Creating new vessels, thereby improving the delivery of oxygen and nutrients to damaged and hypoxic tissue;
(5) And overcoming the intrinsic cell apoptosis.
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Prognosis
The combination of stem cell therapy, supportive therapies, and rehabilitation, Cerebral Palsy patients treated by stem cells customarily observe improvements in the following areas: regained motor development and coordination, improved mental retardation, regained eyesight, increased muscle strength, a decrease in spasticity and improved muscle tone in hypotonic patients. There’s also an improvement in balance and coordination and gross motor skills.
